The Leicester-based firm is now set to roll out the software, already used by energy supplier npower and car rental firm Avis, to two further clients.
The transactional mail arm of Opus Trust Marketing scooped the honour at the first UK Mail awards, held on 2 November in London.
Steve Gass, Optecon IT and operations director and O42 developer, said: "We're thrilled. We're very happy to have been chosen."
O42 beat off competition from Education Direct, Moving Technologies and Pitney Bowes to win the award.