The Derby-based business is being led by ex CT & Line director Colin Taylor who takes on a business development role at the new business.
Nustream Europe will handle the distribution and development of its Proofstream products, which include Proofstream Pro, Lite and Enterprise editions into the European and Asian markets
Colin Taylor, Nustream business development manager for Europe and Asia, said: "The team at Nustream bring a wealth of experience and understanding to this area of software development, and that is what separates Proofstream from other products currently on the market.
"We are convinced that Proofstream represents both a price and performance breakthrough for this sector."
The latest iteration of the Proofstream software is version 6.0, which is targeted at printers, publishers, print management companies, and brand owners.
Its software offers a range of web-based collaborative proofing and workflow tools that the company claimed handle each step of the proofing and file handling process.
Taylor added: "Proofing and the job approval cycle is a critical area in terms of both productivity and profit.
"Research has shown that errors at this stage, such as the failure to carry out a correction, can cost the printer more money than any other production problem."
Nustream Europe now plans to hire suitable distributors as well as holding discussions with potential OEMs.
Taylor said: ""We already have a number of UK resellers in place, and further companies have already expressed an interest.
"Initially our main focus is likely to be on UK, France, Germany, Italy and Spain, but we are still interested in hearing from potential representatives from other territories."
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