The iconic Wapping print facility was closed following the construction of a supersite in Broxbourne.
Its office-based staff were also expected to leave the site, with locations on the South Bank and Canary Wharf favourites for a move.
However, News Corporation this week has announced that the riverside location will be turned into a "campus" for its UK business.
Joining News International on the 20-acre site, which is expected to be re-developed by 2012 in time for the London Olympics, will be Harper Collins, MySpace, Dow Jones, Fox and other related businesses.
News Corporation said it believed the site would allow its subsidiary companies to work closer together. Architects Future Systems will lead the project.
James Murdoch, chairman and chief executive for Europe and Asia at News Corporation, said: "Throughout our history, News Corporation has challenged conventions and we hope this building will provide benefits to the business that can't be found in traditional commercial real estate.
"Wapping is not only important as a physical site, but also it is a symbol of how bold individuals, working together, can advance the world of media and thereby contribute to life in Britain."
News International reveals plans for former print site at Wapping
News International is to consolidate its UK operations at the former print site in Wapping, East London.