De Man has been CFO of the group for nearly seven years.
New CFO Fiona Lam officially takes up the role tomorrow (15 October).
Lam was most recently CFO of electronic engineering tech firm Neways Electronics International.
Agfa CEO Pascal Juéry said he was delighted to welcome Lam to the leadership team.
“I am convinced that Fiona's extensive, international experience in transformation in diverse IT and industrial environments will prove to be invaluable to Agfa, as we are currently refocusing our organisation around a number of future-oriented, promising activities.
“I also wish to express my gratitude to Dirk De Man for his dedicated and valuable contributions to the transformation of our group.”
Lam commented: “I look forward to leveraging my experience to help Agfa advance on its ongoing transformation journey. I am convinced that the company has the right technologies, skills and strategies to succeed in the growth markets it has selected.”
Agfa will announce its Q3 results on 14 November.