The direct marketing print management business will use the new site to serve a large number of its clients and will be headed up by Sarah Pickering, who has previously worked at Venturini and Direct Link.
The opening comes more than two years after the company established a Scottish site in Edinburgh.
Managing director Peter Frings said: "It makes perfect sense to establish a client service base in London where a large number of our clients are also located."
He added: "Sarah is well-respected in the industry and boasts impeccable account management skills – she will be a great asset to the Brightsource team."
Brightsource, which has its head office in Cheltenham, counts Lloyds TSB, British Heart Foundation, RNIB and the Royal British Legion among its client base.
Brightsource follows up turnover increase with London office
Brightsource has expanded with a new London office, following a 27% year-on-year growth in turnover in 2008.