The Prince officially opened the £9.5m plant, which began operating at the end of 2008, this week.
He received a tour around the plant, which prints the Cambridge News among other titles, and was given a special edition of the publication.
It is the third time the company has been visited by royalty. In 2004 Prince Andrew opened a press expansion, following a visit from Prince Charles at the inauguration of the publishing building at Milton in 1996.
Cambridge Newspapers is a subsidiary of publisher Iliffe News and Media. Lord Iliffe was on hand to greet the Prince.
Prince Edward visits Cambridge Newspapers' print site
Cambridge Newspapers' printing facility has been given royal approval following a visit by His Royal Highness Prince Edward.