The company plans to shut the print production operation at Port Dundas, citing declining volumes and the facility proving "unsustainable" to maintain.
Linda Holden, head of group human resources at DC Thomson, said: "The decision to enter into consultation with staff at our Port Dundas facility in Glasgow has been taken with great regret.
"It has been made on the basis that the plant has become unsustainable."
If the plant is to close, Port Dundas, which currently produces The Sunday Post and a range of contract printing services, would cease production in 2012.
"We intend to work with our staff to ensure the best possible outcome for each individual during this difficult period," added Holden.
Employing more than 2,000 people across sites in Scotland, Manchester and London, the company produces more than 100 million copies of its newspapers, books and other titles each year.
In June last year, the company announced that it was to close its Dundee site with the loss of 350 jobs in its gravure, sheetfed and bookbinding operations.
This was on the back 45 jobs being shed at the Glasgow site four months earlier in February.
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