It continues the ongoing contraction that the web sector has seen over the past few months, which many printers hope will ultimately lead to a dramatic rise in prices.
Wyndeham Group chief executive Paul Utting has been unavailable today, however he issued a press statement claiming that the move was taken due to the "severe stress" the sector was under.
He said: "Even an operation like Wyndeham Roche, with modern equipment, needs to make changes in order to remain viable. It is inevitable that similar cost-saving programmes will be implemented across the sector."
All departments of the Cornwall-based site, which employs 340 full-time staff, will affected by the move, which is subject to a 30-day consultation.
Wyndeham Group took on Roche when its parent group Walstead Investments acquired St Ives' web division in April.
A review of the business upon completion concluded that due to "the ongoing poor financial performance of the company" cost savings would need to be made.
Last week, Polestar announced it would make 150 redundancies, a few weeks after it had joined Wyndeham in cutting capacity.
Further announcements are expected from the sector in the coming months.