According to reports, some 28 staff are at risk of redundancy as a result of the planned closure, which will see the printing of titles including the Reading Post transferred to Trinity Mirror's Watford site.
A Trinity Mirror spokesman said: "Trinity Mirror Printing Reading has announced that it will not be renewing the lease on its Tessa Road site in Reading when it expires in early 2014.
"We have entered into a period of consultation with all affected staff."
It is understood that alternative roles will be available at Watford for some of the affected print staff.
Excluding Reading, Trinity Mirror has nine other print sites around the UK, which are used to print its own titles and for contract printing.
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