Launched in 1978, the magazine's most recent ABC for 2008 was 54,009, however the final issue, which will hit newsstands this week, will be the August edition.
It is thought the closure will result in around a dozen redundancies, although exact numbers are not yet known.
PCW is currently printed at St Ives Roche.
Incisive Media cited the slump in the advertising market as being behind the decision to declare the title as "no longer economically viable".
"Sadly, no amount of hard work or innovation was going to turn around the structural decline in advertising and newsstand sales. The depth of this recession and the ease of access to information online has only served to accelerate the long-term downward trend within this particular sector," said managing director Graham Harman.
Incisive also publishes the ComputerActive consumer title, as well as Computing and CRN B2B technology magazines within its portfolio.
Also see:
Reader reaction: Is the traditional magazine model now broken?