The decision follows a four-week consultation period with staff, which ended on Monday (19 May).
The 27 jobs, 15 in Brighton and 12 in Swindon, will be carried out by the Indian operations of US firm, Express KCS.
Pre-press staff design adverts and check pages before printing, but this work will now be contracted out to Express KCS – an American firm with sites in India.
A statement to staff from Ian Hunter, group production manager of Newsquest Sussex, said the decision followed the installation of proofing and workflow software.
"Newsquest is continually looking at production efficiencies," it said.
"This is particularly important given the current external challenges and pressures on our business."
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"Well done all involved... great to see the investment to increase the productivity in the same footprint- much more sustainable than popping another one up."
"From 1949 until the late 2000s Remploy had a network of government-subsidised factories that offered employment specifically to disabled people, originally often war veterans or victims of industrial..."
"Does appear an odd decision as with that level of shareholder funds they would be liable for the staff redundancy and cover the insolvency costs. It’s not like they could take the money and dodge..."
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