The decision follows a four-week consultation period with staff, which ended on Monday (19 May).
The 27 jobs, 15 in Brighton and 12 in Swindon, will be carried out by the Indian operations of US firm, Express KCS.
Pre-press staff design adverts and check pages before printing, but this work will now be contracted out to Express KCS – an American firm with sites in India.
A statement to staff from Ian Hunter, group production manager of Newsquest Sussex, said the decision followed the installation of proofing and workflow software.
"Newsquest is continually looking at production efficiencies," it said.
"This is particularly important given the current external challenges and pressures on our business."
Have your say in the Printweek Poll
Related stories
Latest comments
"Utilities, paper and ink but probably not transport, couriers, finisher’s for example"
"Bound to be, most likely those not key suppliers along with HMRC"
"And now watch for those reversion charges to come in thick and fast, for the slightest deviation from the mailing specification 😉😂"
Up next...
Xerox reinvention continues
Xerox to acquire Lexmark in $1.5bn A4 colour printing move
Moves to Brighouse
The Flow Group buys Modern Bookbinders, saving 94-year-old firm
Festive coverage
Wishing our wonderful readers a merry Christmas and happy New Year
Enables print up to 3.2m wide