The newspaper giant will move the printing of its North West newspaper titles, which include the Liverpool Echo and Liverpool Post, to its recently upgraded facility at Oldham.
Moving the newspapers is expected to take 15 months with the subsequent closure of the plant taking place at the end of 2009.
An additional £7.5m is to be invested in the Oldham plant to create an extension to the presses which came on line in December 2007. This will provide each of the titles moving across with full colour printing, as well as improved quality.
A consultation will take place into the employees' future, and Trinity has said that there may be scope for some of the staff to move across to the Oldham plant.
However, the publisher has said that it was not financially viable to upgrade the plant.
Rupert Middleton, group director of manufacturing, said: "This has been a very difficult decision given our history of printing in Liverpool and the impact on our team there.
"But this plan will give the North West publishing business clear benefits of improved print quality, full colour and enhanced inserting capabilities that are currently unavailable in Liverpool as well as reduced costs."
The move comes just weeks after Sly Bailey, chief executive of Trinity Mirror, vowed to cut £20m of costs from the business following a pre-tax loss of £20.6m in its interim results.
100 jobs could go as Trinity Mirror Printing moves out of Liverpool
Trinity Mirror Printing has announced plans to close its Liverpool plant, risking the jobs of around 100 staff.