The full-colour machine targets the B2 market and is effectively an offset press with inkjet technology that can run at 1,600 sheets per hour.
According to Screen European marketing manager Tim Taylor, the press is due to be commercially available early next year.
"It is early days and we are using Drupa to find out what the market wants," he said.
Taylor added the Jet SX is capable of running at faster speeds and can print on both coated and uncoated paper.
The press prints using water-based inks, but Screen did not reveal the head technology behind the Jet SX. Taylor said the heads have been developed from "existing technology".
Screen has also announced that it has designed new single-pass inkjet assembly technology. The 600dpi UV head is being demonstrated at Drupa, running at 55m per hour.
The advanced head is designed to improve quality by shortening the time taken between the application of the UV ink droplets. Screen has not announced when this will be commercially available.
"It is very flexible technology that can be used in many different ways," added Taylor.
In addition, Screen is showing its new workflow for the print-on-demand market. Equiosnet features Adobe's PDF Print Engine and adds transpromo to Screen's workflow range, which includes Trueflow.
"In the longer term, we would expect Equiosnet to merge with Trueflow," added Taylor.
Screen's other digital products, the Truepress Jet 520, Jet 2500 and Jet 650UV were also on display. The Jet 650 is being shown outside Japan for the first time at Drupa while Screen has announced a high-speed model for the Jet 520.
The new addition can print at speeds of 1,680 A4 pages per minute and has an ink saving of 30%.
Screen has also launched an entry-level version of the Jet 520, which can print at speeds of 32m per minute.
Screen debuts first-ever cut-sheet inkjet machine
Screen has unveiled the world's first cut sheet inkjet machine at Drupa, the Truepress Jet SX.