The lecture is titled New Chapter or Last Page? and deals with how the book industry will find its place in the digital age.
As well as her role at Random House, Rebuck co-launched World Book Day in 1998 and is currently chairing the Steering Committee of Quick Reads, an adult literacy project designed to encourage literacy among all sectors of society.
She is a Non-Executive Director of BSkyB, serves on the Council of the Royal College of Art and is a Trustee of the Work Foundation and the National Literacy Trust.
The event will take place on Monday 10 March at Stationers Hall.
Places are limited to 240, and tickets are available for £25 by calling 020 7246 0988 or emailing helena@stationers.org.
Random House chief to headline Stationers' lecture
The Stationers' Annual Lecture 2008 is to feature Random House chief executive Gail Rebuck CBE giving the keynote speech.