The manufacturer will showcase the new machine, in addition its XMF web-to-print system, at the 27-29 March event.
The eight-colour printer, which was unveiled in September, can print at a resolution of up to 1,200dpi and has received large levels of interest from UK customers since its launch.
It offers production speeds of up to 20sqm an hour for applications such as posters and point-of-purchase materials.
Fujifilm is targeting the 1,610mm-wide Acuity LED 1600 at companies producing short-run print jobs such as window displays and uses UV-curable ink which emits no VOCs.
According to Fujifilm, these inks have fast-drying properties on a broad range of substrates such as PET, acrylic, and polycarbonate.
Graham Leeson, marketing communications manager of graphic systems at Fufifilm, said the combination of quality and productivity puts the LED 1600 at "the forefront" of development.
He said: "This new machine features the latest advances in LED UV technology, so we will be putting it through its paces to demonstrate its quality, performance and versatility."
Fujifilm to give UK debut to Acuity LED 1600 at Sign & Digital 2012
Fujifilm will give a UK debut to its latest UV printer, the Acuity LED 1600, which emits no VOCs, at Sign & Digital UK 2012.